tert-Butyl bromoacetate → HCID 12135274, compound

HRID 1760563Notes

Reaction equation

HRID 1760563 reaction equation
[CH2:1]([C:8]1[O:9][C:10]2[CH:27]=[CH:26][CH:25]=[CH:24][C:11]=2[C:12]=1[C:13]([C:15]1[CH:20]=[C:19]([I:21])[C:18]([OH:22])=[C:17]([I:23])[CH:16]=1)=[O:14])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Br[CH2:29][C:30]([O:32]C(C)(C)C)=[O:31]>C(O)=O>[CH2:1]([C:8]1[O:9][C:10]2[CH:27]=[CH:26][CH:25]=[CH:24][C:11]=2[C:12]=1[C:13]([C:15]1[CH:20]=[C:19]([I:21])[C:18]([O:22][CH2:29][C:30]([OH:32])=[O:31])=[C:17]([I:23])[CH:16]=1)=[O:14])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 79177tert-Butyl bromoacetateHCID 12135273HCID 12135273, compound

Product 1

HCID 12135274HCID 12135274, compound

Reagents, catalysts & solvents 1

HCID 284Formic AcidSolvent

Procedure

This compound was prepared from (2-benzyl-benzofuran-3-yl)-(3,5-diiodo-4-hydroxy-phenyl)-methanone and tert-butyl bromoacetate in substantially the same manner, as described in Example 2. Formic acid was used in the place of trifluoroacetic acid. The product was obtained as an off-white solid, mp 144-146° C.; MS m/e 638 (M+);

Workup

  1. customThe product was obtained as an off-white solid, mp 144-146° C.

Sources & evidence

ORD record
ord-c9ab4f6076294d7695877b92365582ac
Source dataset
uspto-grants-2005_01
Patent number
US06844358B2

Reaction notes

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