HCID 10005176, compound → HCID 12133220, compound

HRID 1760571Notes

Reaction equation

[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([C:16]2[CH:17]=[C:18]3[C:23](=[CH:24][CH:25]=2)[N:22]=[C:21]([O:26]C)[CH:20]=[C:19]3[C:28]2[S:29][C:30]([Cl:33])=[CH:31][CH:32]=2)([C:10]2[N:11]([CH3:15])[CH:12]=[N:13][CH:14]=2)[OH:9])=[CH:4][CH:3]=1.ClC1C=CC(C(C2C=C3C(=CC=2)N=C(OC)C=C3C2SC(C)=CC=2)(C2N(C)C=NC=2)O)=CC=1>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([OH:9])([C:10]2[N:11]([CH3:15])[CH:12]=[N:13][CH:14]=2)[C:16]2[CH:17]=[C:18]3[C:23](=[CH:24][CH:25]=2)[NH:22][C:21](=[O:26])[CH:20]=[C:19]3[C:28]2[S:29][C:30]([Cl:33])=[CH:31][CH:32]=2)=[CH:4][CH:3]=1

Participants

Reactant 2

HCID 10005176HCID 10005176, compound

HCID 22596114HCID 22596114, compound

Product 1

HCID 12133220HCID 12133220, compoundYield 94.4%

Procedure

The same procedure was used as that in example 2, except that (4-chloro-phenyl)-[2-methoxy-4-(5-chloro-thiophen-2-yl)-quinolin-6-yl]-(3-methyl-3H-imidazol-4-yl)-methanol (0.194 g, 0.391 mmol) was used in the place (4-chloro-phenyl)-[2-methoxy-4-(5-methyl-thiophen-2-yl)-quinolin-6-yl]-(3-methyl-3H-imidazol-4-yl)-methanol, to give title compound as a white solid (0.178 g, 0.369 mmol, 94% yield).

Sources & evidence

ORD record: ord-c7bead52bcf6483f85553c906f40de15
Source dataset: uspto-grants-2005_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06844357B2

Reaction notes

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