Potassium Carbonate → HCID 20824954, compound

Participants

Reaction Conditions

Reaction Steps

1.2 g (R)-6-bromo-8-fluoro-4-methyl-3,4-dihydro-2H-pyrazino[1,2-a]indol-1-one was dissolved in 12 ml N,N-dimethylformamide under argon. 0.45 gTetrakis-(triphenylphosphine)palladium, 1.56 g potassium carbonate and 0.55 ml trimethylboroxine were added. The mixture was heated overnight at 110° C., allowed to cool to room temperature, filtered over dicalite and washed through with tetrahydrofuran. The solvents were evaporated under reduced pressure and the residue purified by column chromatography on silica gel (1:1 to 1:3 toluene/ethyl acetate) to afford the title product as an off-white solid. Yield: 300 mg ISP-MS: m/e 233.1 ([M+H]+).

Provenance & Evidence