Dichloromethane → HCID 68888976, compound

Participants

Reaction Steps

A solution of 80.0 mg (0.26 mmol) 6-cyano-4-methyl-3,4-dihydro-1H-pyrazino[1,2-a]indole-2-carboxylic acid tert-butyl ester in 3 ml dichloromethane was cooled to 0° C. and treated dropwise with 1 ml trifluoroacetic acid. After 30 min. the solution was concentrated at a rotary evaporator and the residue was chromatographed on silica gel (0.032-0.063 mm) with ethyl acetate: methanol: ammonia (9:1:0.1) as eluant. The product was dissolved in 3 ml diethyl ether and treated dropwise with 43 μl of a 6M hydrochloric acid solution in ethyl acetate. The suspension was filtered and the solid was dried under high vacuum to give the desired compound as light yellow crystals. EI-MS:: m/e=211.2 ([M]).

Provenance & Evidence