(s)-Tert-butyl 5-methyl-1,2,3-oxathiazolidine-3-carboxylate 2,2-dioxide → (r)-8-Bromo-7-fluoro-4-methyl-3,4-dihydro-1h-pyrazino[1,2-a]indole-2-carboxylic acid tert-butyl ester

Participants

Reaction Steps

The title compound, ISP-MS: m/e=383.2 ([M+H]+) and m.p. 116-118° C., was prepared in accordance with the general method of example 26b) and c) from 5-bromo-2-[dimethyl-(1,1,2-trimethyl-propyl)-silanyloxymethyl]-6-fluoro-1H-indole and (S)-5-methyl-2,2-dioxo-[1,2,3]oxathiazolidine-3-carboxylic acid tert-butyl ester.

Provenance & Evidence