Water → HCID 68890021, compound

Participants

Reaction Steps

To a solution of 0.240 g (S)-4-[dimethyl-(1,1,2-trimethyl-propyl)-silanyloxymethyl]-7-trifluoromethyl-3,4-dihydro-2H-pyrazino[1,2-a]indol-1-one in 3 ml THF was added 1.2 ml of a 1M solution of lithium aluminium hydride in THF. The mixture was heated to reflux for 1 h. The reaction mixture was cooled to room temperature and the 10 ml ethyl acetate and 10 ml water were added. The phases were separated and the organic phase was purified by chromatography on silica gel with 190:10:1 dichloromethane:methanol:25% aqueous ammonia eluant to yield 0.11 g of the title compound as white crystals (m.p.: 126-127° C.).

Provenance & Evidence