HCID 69587377, compound → HCID 21912336, compound

HRID 1760688Notes

Reaction equation

HRID 1760688 reaction equation
C[O:2][C:3](=[O:33])[CH:4]([CH2:9][C:10]1[C:11]([NH:23][C:24]2[C:29]([CH3:30])=[CH:28][C:27]([CH3:31])=[CH:26][C:25]=2[CH3:32])=[N:12][C:13]([CH3:22])=[CH:14][C:15]=1[O:16][CH:17]([CH2:20][CH3:21])[CH2:18][CH3:19])C(OC)=O>O>[CH2:18]([CH:17]([O:16][C:15]1[CH:14]=[C:13]([CH3:22])[N:12]=[C:11]([NH:23][C:24]2[C:29]([CH3:30])=[CH:28][C:27]([CH3:31])=[CH:26][C:25]=2[CH3:32])[C:10]=1[CH2:9][CH2:4][C:3]([OH:33])=[O:2])[CH2:20][CH3:21])[CH3:19]

Participants

3

Reactant 1

HCID 69587377HCID 69587377, compound

Product 1

HCID 21912336HCID 21912336, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Hydrolysis of 2-[4-(1-ethyl-propoxy)-6-methyl-2-(2,4,6-trimethyl-phenylamino)-pyridin-3-ylmethyl]-malonic acid dimethyl ester with phosphoic/water at reflux to give the title compound as a white foam. Anal. For C23H32N2O3. 3/4H2O calc.: C,69.40; H. 8.48; N, 7.04; found: C, 69.17; H, 8.62; N. 6.90.

Workup

  1. temperatureat reflux

Sources & evidence

ORD record
ord-0484225b48c349eeb74008f419151601
Source dataset
uspto-grants-2005_01
Patent number
US06844351B1

Reaction notes

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