HRID1760713

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID74866

3-Methoxyphenylethylamine

C9H13NO

结构：COc1ccccc1CNC(=O)c1cc2cc(C[C@@H](C)NC[C@H](O[Si](C)(C)C(C)(C)C)c3ccc(O)c(CO)c3)ccc2[nH]1

HCID12988826

未命名化合物

PRODUCTS

生成物

结构：COc1cccc(CCNC(=O)c2cc3cc(C[C@@H](C)NC[C@H](O[Si](C)(C)C(C)(C)C)c4ccc(O)c(CO)c4)ccc3[nH]2)c1

HCID59979276

未命名化合物

PROCEDURE

实验过程

Prepared analogously to 5-[(2R)-2-({(2R)-2-{[tert-butyl(dimethyl)silyl]oxy}-2-[4-hydroxy-3-(hydroxymethyl)phenyl]ethyl}amino)propyl]-N-(2-methoxybenzyl)-1H-indole-2-carboxamide using 3-methoxyphenethylamine to give the title compound as a pale brown foam.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-a94edff378464e0eae46a44995fa9530
来源数据集: uspto-grants-2005_01
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06844362B2
来源说明: uspto-grants-2005_01

反应 SMILES

[Si:1]([O:8][C@H:9]([C:36]1[CH:41]=[CH:40][C:39]([OH:42])=[C:38]([CH2:43][OH:44])[CH:37]=1)[CH2:10][NH:11][C@H:12]([CH3:35])[CH2:13][C:14]1[CH:15]=[C:16]2[C:20](=[CH:21][CH:22]=1)[NH:19][C:18]([C:23]([NH:25][CH2:26][C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][C:28]=1[O:33][CH3:34])=[O:24])=[CH:17]2)([C:4]([CH3:7])([CH3:6])[CH3:5])([CH3:3])[CH3:2].[CH3:45]OC1C=C(C=CC=1)CCN>>[Si:1]([O:8][C@H:9]([C:36]1[CH:41]=[CH:40][C:39]([OH:42])=[C:38]([CH2:43][OH:44])[CH:37]=1)[CH2:10][NH:11][C@H:12]([CH3:35])[CH2:13][C:14]1[CH:15]=[C:16]2[C:20](=[CH:21][CH:22]=1)[NH:19][C:18]([C:23]([NH:25][CH2:26][CH2:27][C:32]1[CH:31]=[CH:30][CH:29]=[C:28]([O:33][CH3:34])[CH:45]=1)=[O:24])=[CH:17]2)([C:4]([CH3:5])([CH3:7])[CH3:6])([CH3:2])[CH3:3]