HuagongsheHuagongshe Chemistry Print Report · For research reference only
Donepezil → 5,6-Dimethoxy-2-(4-pyridyl)methylene-1-indanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Donepezil | HCID 3152 | — |
| Reactant | 4-Pyridinecarboxaldehyde | HCID 13389 | — |
| Reactant | 5,6-Dimethoxy-1-indanone | HCID 75018 | — |
| Product | 5,6-Dimethoxy-2-(4-pyridyl)methylene-1-indanone | HCID 53395132 | — |
Reaction Steps
Patent application EP 711756 describes the preparation of Donepezil by reaction of 5,6-dimethoxy-1-indanone with pyridin-4-aldehyde to give 5,6-dimethoxy-2-(pyridin-4-yl)methylene indan-1-one. Reaction with benzyl bromide afforded 1-benzyl-4-(5,6-dimethoxyindan-1-on-2-ylidene)methylpyridinium bromide. Hydrogenation in the presence of platinum oxide afforded Donepezil (Scheme 4).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06844440B2 |
| Source dataset | uspto-grants-2005_01 |
| ORD ID | ord-50cda0d5b8fd4ea7afe97eb1768d1805 |
| Source note | uspto-grants-2005_01 |