HCID 22596699, compound → HCID 22596732, compound

HRID 1760743Notes

Reaction equation

HRID 1760743 reaction equation
[NH2:1][C:2]1[C:11]([N+:12]([O-])=O)=[CH:10][CH:9]=[C:8]2[C:3]=1[C:4](=[O:17])[NH:5][C:6](=[O:16])[N:7]2[CH3:15]>CO.[Pd]>[NH2:1][C:2]1[C:11]([NH2:12])=[CH:10][CH:9]=[C:8]2[C:3]=1[C:4](=[O:17])[NH:5][C:6](=[O:16])[N:7]2[CH3:15]

Participants

4

Reactant 1

HCID 22596699HCID 22596699, compound

Product 1

HCID 22596732HCID 22596732, compoundYield 103.5%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

A suspension of 5-amino-1-methyl-6-nitroquinazolin-2,4-dione (400 mg, 1.64 mmol) in MeOH (70 mL) was hydrogenated over 10% Pd/C (150 mg) in a Parr shaker at 50 psi until uptake ceased. The catalyst was removed by filtration and the filtrate concentrated to yield 5,6-diamino-1-methylquinazolin-2,4-dione (350 mg, 99% crude).

Workup

  1. customThe catalyst was removed by filtration
  2. concentrationthe filtrate concentrated

Sources & evidence

ORD record
ord-88191fac4f5b42b0833075bd3cd1fc29
Source dataset
uspto-grants-2005_01
Patent number
US06844435B2

Reaction notes

Loading…