Nitric Acid → HCID 135813639, compound

Participants

Reaction Steps

A solution of the above quinazolinone (1.26 g, 7.0 mmol) in conc. H2SO4 (7 mL) was cooled to −20° C., and 90% HNO3 (0.49 g, 7.0 mmol) was added with stirring. Stirring continued for 1 h at −20° C., and 2 h at room temperature. The mixture was poured onto ice, filtered, washed with water and dried to give 5-chloro-6-nitroquinazolin-4-one, along with the 8-nitro isomer in a 4:1 ratio. Three recrystallizations from EtOH gave the product as a 6:1 ratio of isomers (0.85 g).

Provenance & Evidence