Hydrochloric Acid → HCID 22596838, compound

Participants

Reaction Steps

A solution of methyl 3-fluoro-4-[3-pentyl-3-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-ureido]-benzoate (17 mg) in 10 mL THF/3 mL methanol/3 mL water was treated with lithium hydroxide hydrate (20 mg). The mixture was stirred at room temperature for two hours. The mixture was diluted with 5 mL water and the pH was adjusted to 2 with conc. HCl. The mixture was extracted with three 10 mL portions of ether. The combined organic extracts were dried over MgSO4, filtered and concentrated in vacuo, giving a brown solid. The product was purified by trituration in hexanes, yielding 12 mg 3-fluoro4-[3-pentyl-3-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-ureido]-benzoic acid as a yellow solid. M.P. 151-157° C.

Provenance & Evidence