Phenol → Lauryl phenyl ether

Participants

Reaction Conditions

Reaction Steps

Phenol (47 g; 0.5 mol) is dissolved in DMF (300 ml), and K2CO3 (82.93 g; 0.6 mol) is added. 1-Bromododecane (124.6 g; 0.5 mol) is then added dropwise to the solution at 70° C. After a further 15 hours at 80° C., cooling to 25° C. is carried out, followed by dilution with water (500 ml) and extraction with tert-butyl methyl ether (2×250 ml). The combined organic extracts are washed with water (2×250 ml) and dried over Na2SO4. After filtration, concentration to dryness by evaporation is carried out.

Provenance & Evidence