Benzylamine → HCID 12043217, compound

Participants

Reaction Steps

To 0.3 g (1.19 mmol) of 2-chloro-6,7-diethoxyquinoxaline is added 2 mL of benzylamine. This mixture is heated under nitrogen overnight to 120° C. The resulting mixture is partitioned between CH2Cl2 and saturated NaHCO3 solution. The organic layer is concentrated, and the residue chromatographed (30:1 CH2Cl2; EtOH) to provide 0.337 g of the product as a yellow solid in 87.6% yield (m.p. 136° C.). Anal. Calcd for C19H21N3O2: C, 70.57; H, 6.54; N, 12.99. Found: C, 70.54; H, 6.66; N, 12.80.

Provenance & Evidence