HCID 69639561, compound → HCID 69639714, compound

HRID 1760920Notes

Reaction equation

HRID 1760920 reaction equation
[ClH:1].[NH2:2][C:3]1[CH:8]=[CH:7][N:6]([CH:9]2[O:13][CH:12]([CH2:14][O:15][C:16](=[O:22])[CH:17]([NH2:21])[CH:18]([CH3:20])C)[CH:11]([OH:23])[CH:10]2[OH:24])[C:5](=[O:25])[N:4]=1.Cl.NC1C=CN([CH:34]2O[CH:37]([CH2:39]OC(=O)C(N)C)[CH:36](O)[CH:35]2O)C(=O)N=1>>[ClH:1].[NH2:2][C:3]1[CH:8]=[CH:7][N:6]([CH:9]2[O:13][CH:12]([CH2:14][O:15][C:16](=[O:22])[CH:17]([NH2:21])[CH2:18][C:20]3[CH:39]=[CH:37][CH:36]=[CH:35][CH:34]=3)[CH:11]([OH:23])[CH:10]2[OH:24])[C:5](=[O:25])[N:4]=1

Participants

3

Reactant 2

HCID 69639561HCID 69639561, compound2×HCID 69639819HCID 69639819, compound2×

Product 1

HCID 69639714HCID 69639714, compound

Procedure

In similar fashion substituting boc-L-valine and boc-L-alanine there was obtained respectively, 2-amino-3-methyl-butyric acid 5-(4-amino-2-oxo-2H-pyrimidin-1-yl)-3,4-dihydroxy-tetrahydro-furan-2-ylmethyl ester hydrochloride (compound 18; MH+=384; MNa+=406) and 2-amino-propionic acid 5-(4-amino-2-oxo-2H-pyrimidin-1-yl)-3,4-dihydroxy-tetrahydro-furan-2-ylmethyl ester hydrochloride (compound 20; MH+=356; MNa+=378).

Sources & evidence

ORD record
ord-4d2df4ea18bf4131af4370f3b0885c7b
Source dataset
uspto-grants-2005_01
Patent number
US06846810B2

Reaction notes

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