4-Nitrophenol → HCID 22593929, compound

HRID 1760940Notes

Reaction equation

[S:1]1[C:6]2[CH:7]=[CH:8][CH:9]=[CH:10][C:5]=2[N:4]([CH2:11][CH2:12][O:13][C:14]2[CH:19]=[CH:18][C:17]([CH2:20][CH:21]([O:25][CH2:26][CH3:27])[C:22]([OH:24])=[O:23])=[CH:16][CH:15]=2)[CH2:3][CH2:2]1.[N+:28]([C:31]1[CH:36]=[CH:35][C:34](O)=[CH:33][CH:32]=1)([O-:30])=[O:29]>>[S:1]1[C:6]2[CH:7]=[CH:8][CH:9]=[CH:10][C:5]=2[N:4]([CH2:11][CH2:12][O:13][C:14]2[CH:15]=[CH:16][C:17]([CH2:20][CH:21]([O:25][CH2:26][CH3:27])[C:22]([O:24][C:34]3[CH:35]=[CH:36][C:31]([N+:28]([O-:30])=[O:29])=[CH:32][CH:33]=3)=[O:23])=[CH:18][CH:19]=2)[CH2:3][CH2:2]1

Participants

Reactant 2

HCID 9804-Nitrophenol

HCID 9909435HCID 9909435, compound

Product 1

HCID 22593929HCID 22593929, compoundYield 38%

Procedure

The title compound (0.15 g, 38%) was prepared as a yellow liquid from 3-[4-[2-(2,3-dihydro-1,4-benzoxazin-4-yl)ethoxy]phenyl]-2-ethoxypropanoic acid (0.3 g, 0.77 mmol) obtained in example 29 and 4-nitrophenol by an analogous procedure to that described in example 32.

Sources & evidence

ORD record: ord-b0978c23f42c4df2a7171244d764d719
Source dataset: uspto-grants-2005_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06846824B2

Reaction notes

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