1,4-Dioxane hydrochloride → HCID 86584507, compound

HRID 1760946Notes

Reaction equation

HRID 1760946 reaction equation
[CH2:1]([O:8][C:9](=[O:35])[CH2:10][O:11][C@@H:12]([C:29](=[O:34])[N:30]([O:32][CH3:33])[CH3:31])[C@@H:13]([NH:21]C(OC(C)(C)C)=O)[CH2:14][C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[ClH:36].O1CCOCC1>>[ClH:36].[CH2:1]([O:8][C:9](=[O:35])[CH2:10][O:11][C@@H:12]([C:29](=[O:34])[N:30]([O:32][CH3:33])[CH3:31])[C@@H:13]([NH2:21])[CH2:14][C:15]1[CH:16]=[CH:17][CH:18]=[CH:19][CH:20]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 204431481,4-Dioxane hydrochlorideHCID 86584509HCID 86584509, compound

Product 1

HCID 86584507HCID 86584507, compound

Procedure

(1R,2S)-[2-tert-Butoxycarbonylamino-1-(methoxy-methyl-carbamoyl)-3-phenylpropoxy]-acetic acid benzyl ester (170 mg, 0.35 mmol) was dissolved in 4N HCl-dioxane (2 mL) for 1.5 hours at 25° C., concentrated, the residue coevaporated with ether and dried giving an oil (163 mg). MS 387 (MH+, 100%).

Workup

  1. concentrationconcentrated
  2. customdried

Sources & evidence

ORD record
ord-d0c594e4df24444e9b8eeb1207fe37f1
Source dataset
uspto-grants-2005_01
Patent number
US06846820B2

Reaction notes

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