4-Piperidinol, 1-methyl- → HCID 9957766, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 2-chloro-4-[2-methyl-5-(2-morpholinopyrid-4-ylcarbonylamino)anilino]pyrimidine (0.13 g), 4-hydroxy-N-methylpiperidine (0.087 g) and potassium tert-butoxide (1M in tert-butanol, 1.5 ml) was stirred and heated to 140° C. for 1 hour. The mixture was partitioned between water and methylene chloride and the organic phase was washed with brine, dried over sodium sulphate and evaporated. There was thus obtained the title compound as a solid (0.11 g); NMR Spectrum: (DMSOd6) 1.45 (m, 2H), 1.88 (m, 2H), 1.97 (m, 2H), 2.05 (s, 3H), 2.15 (s, 3H), 2.23 (m, 2H), 3.5 (m, 4H), 5.7 (m, 4H), 4.77 (m, 1H), 6.28 (d, 1H), 6.89 (m, 1H), 7.1 (m, 1H), 7.21 (m, 1H), 7.24 (s, 1H), 7.47 (m, 1H), 7.9 (m, 1H), 7.98 (d, 1H), 8.25 (m, 1H), 8.9 (s, 1H), 10.24 (s, 1H); Mass Spectrum: M+H+ 504.

Provenance & Evidence