Trifluoroacetic acid → HCID 22594114, compound

Participants

Reaction Steps

Trifluoroacetic acid (5 ml) was added to a solution of 2(1-tert-butoxycarbonylpiperidin-4-yloxy)-4-[2-methyl-5-(2-morpholinopyrid-4-ylcarbonylamino)anilino]pyrimidine (0.212 g) in methylene chloride (5 ml) and the resultant mixture was stirred at ambient temperature for 2 hours. The mixture was evaporated and the residue was partitioned between methylene chloride and water. The aqueous phase was passed through an ion exchange column (isolute SCX column from International Sorbent Technology Limited, Hengoed, Mid-Glamorgan, UK) using a 99:1 mixture of methanol and a saturated aqueous ammonium hydroxide solution as eluent. The product so obtained was triturated under diethyl ether and there was thus obtained the title compound as a solid (0.065 g); NMR Spectrum: (DMSOd6) 1.2 (m, 2H), 1.87 (m, 2H), 2.17 (s, 3H), 2.19 (s, 3H), 2.27 (m, 2H), 2.95 (m, 2H), 3.5 (m, 4H), 3.7 (m, 4H), 4.85 (m, 1H), 6.27 (d, 1H), 7.1 (m, 1H), 7.21 (s, 1H), 7.23 (m, 1H), 7.5 (m, 1H), 7.9 (m, 1H), 8.0 (d, 1H), 8.27 (m, 1H), 9.0 (s, 1H), 10.28 (s, 1H); Mass Spectrum: M+H+ 490.

Provenance & Evidence