Ammonium Hydroxide → HCID 178426576, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 2-chloro-4-[5-(3-fluoro-5-morpholinobenzamido)-2-methylanilino]pyrimidine (0.1 g) and formic acid (1.0 ml) was stirred and heated to 65° C. for 16 hours. The mixture was allowed to cool to ambient temperature and was poured into a dilute aqueous ammonium hydroxide solution. The resultant precipitate was isolated and washed with anhydrous diethyl ether. There was thus obtained the title compound (0.09 g); NMR Spectrum: (DMSOd6) 2.14 (s, 3H), 3.2 (m, 4H), 3.73 (m, 4H), 5.70 (br m, 1H), 6.95 (m, 1H), 7.09 (m, 1H), 7.19 (m, 1H), 7.25 (s, 1H), 7.4 (m, 1H), 7.5 (m, 1H), 7.68 (m, 1H), 10.14 (s, 1H), 10.5 (broad s, 1H); Mass Spectrum: M+H+ 424.

Provenance & Evidence