Morpholine → HCID 22594080, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 4-[5-(3-fluoro-5-morpholinobenzamido)-2-methylanilino]2-methylthiopyrimidine (0.228 g) and morpholine (1 ml) was stirred and heated to 150° C. for 10 days. The reaction mixture was allowed to cool to ambient temperature and poured into water (10 ml). The resultant precipitate was collected by filtration and dried in a vacuum oven at 60° C. for 16 hours. There was thus obtained the title compound (0.175 g); NMR Spectrum: (DMSOd6) 2.18 (s, 3H), 3.21 (m, 4H), 3.59 (m, 8H), 3.74 (m, 4H), 5.98 (d, 1H), 6.96 (m, 1H), 7.09 (m, 1H), 7.18 (m, 1H), 7.26 (m, 1H), 7.38 (m, 1H), 7.89 (d, 1H), 8.01 (m, 1H), 8.49 (s, 1H), 10.07 (s, 1H); Mass Spectrum: M+H+ 493.

Provenance & Evidence