Carbohydrazide → (S)-(1-Methylpiperidin-2-yl)methanol

HRID 1761004Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1761004
NN[C:3](NN)=O.ClC1C=[C:15]2[C:11]([C:12](=[O:18])[C:13](=O)[NH:14]2)=[CH:10][C:9]=1I>>[CH3:3][N:14]1[CH2:15][CH2:11][CH2:10][CH2:9][C@H:13]1[CH2:12][OH:18]

Komponenten

3

Edukt 2

HCID 73948CarbohydrazideHCID 225943886-Chloro-5-iodoindoline-2,3-dione

Produkt 1

HCID 853003(S)-(1-Methylpiperidin-2-yl)methanol

Versuchsvorschrift

Compound (S)-(−)-6 was prepared from carbazide (S)-d and aldehyde C (prepared from 6-chloro-5-iodo-isatin by Method I and Method A) by the procedure described in Example 5. 1H NMR (DMSO-d6) δ 1.10-1.30 (m, 2H), 1.49 (m, 3H), 1.64 (m, 1H), 2.09 (t, 1H), 2.38 (s, 1H), 2.41 (s, 3H), 2.83 (d, 1H), 3.00 (dd, 2H), 3.23 (dd, 2H), 4.13 (s, 3H), 4.18 (q, 1H), 4.31 (q, 1H), 6.90 (s, 1H), 7.30 (s, 1H), 7.85 (s, 1H), 8.04 (s, 1H), 8.14 (s, 1H), 8.38 (s, 1H), 8.41 (s, 1H), 8.45 (s, 1H). ESI-MS m/z 493.2 (100, M+H).

Quellen und Nachweise

ORD-Eintrag
ord-aecf6b59ee87424da30913be2cfdae30
Quelldatensatz
uspto-grants-2005_01
Patentnummer
US06846834B2

Notizen zur Reaktion

Wird geladen…