HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → 2-Fluoro-5-methoxybenzoyl chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 2-Fluoro-5-methoxybenzoic acid | HCID 2774543 | — |
| Catalyst | Dimethylformamide | HCID 6228 | — |
| Product | 2-Fluoro-5-methoxybenzoyl chloride | HCID 22594222 | 101.2% |
Reaction Steps
A mixture of 2-fluoro-5-methoxy-benzoic acid (4.3 g, 25 mmol) and thionyl chloride (68 mL, 937 mmol) and DMF (1 drop) was stirred at RT for 14 hours. The mixture was then evaporated to afford the title compound (4.77 g, 100%) after repeated azeotroping with toluene.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06846832B2 |
| Source dataset | uspto-grants-2005_01 |
| ORD ID | ord-c6f3de25f5534314ab8f0505879369dd |
| Source note | uspto-grants-2005_01 |