Methanol → HCID 22594308, compound

Participants

Reaction Steps

Sodium triacetoxyborohydride (23 g; 108 mmol) is added in small portions to a solution, stirred under an argon atmosphere, of 3-cyanobenzaldehyde (10 g; 63.7 mmol) and 2-aminopyridine (6 g; 63.7 mmol) in 300 ml of 1,2-dichloroethane. After stirring for 12 hours at ambient temperature, the reaction mixture is hydrolysed with methanol and concentrated. The residue obtained is purified by chromotography on silica gel (eluant petroleum ether/ethyl acetate, 3/1 then 2/1 and 1/1) to yield the expected product.

Provenance & Evidence