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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1761069Generated: October 25, 2026

Ethyl indole-2-carboxylate → Ethyl 5-fluoro-1-methyl-1H-indole-2-carboxylate

https://huagongshe.com/reaction/1761069

Reaction equation

Participants

RoleNameHCIDCharge
ReactantEthyl indole-2-carboxylateHCID 73125—
Reactantethyl 5-fluoro-1H-indole-2-carboxylateHCID 2727899—
ProductEthyl 5-fluoro-1-methyl-1H-indole-2-carboxylateHCID 10775338100%

Reaction Steps

According to the procedure of Preparation 1(a), except substituting ethyl 5-fluoro-indole-2-carboxylate for the ethyl-indole-2-carboxylate, the title compound (3.3 g, 100%) was prepared as a white solid: MS (ES) m/e 222 (M+H)+.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06846819B1
Source datasetuspto-grants-2005_01
ORD IDord-1188fe55d0b84b97a13e89d70e07c5c0
Source noteuspto-grants-2005_01