反应详情

To a stirred solution of 3-methyl-2-(methylaminomethyl)benzo[b]thiophene (0.30 g, 1.6 mmole) in 1:1 DMF/CH2Cl2 was added (E)-3-(6aminopyridin-3-yl)acrylic acid (0.33 g, 2 mmole), HOBt H2O (0.27 g, 2 mmole), and DCC (0.41 g, 2 mmole). The reaction was stirred for 16 hr, then was concentrated under vacuum. The residue was taken up in CHCl3, washed with H2O, dried (Na2SO4) and concentrated. Purification by flash chromatography on silica gel (4% methanoUCHCl3) gave the title compound (0.39 g, 72%) as a pale yellow solid: LCMS (ES) m/e 338.2 (M+H)+.

1. concentrationwas concentrated under vacuum
2. washwashed with H2O
3. dry with materialdried (Na2SO4)
4. concentrationconcentrated
5. customPurification by flash chromatography on silica gel (4% methanoUCHCl3)