反应详情

To a solution of 2.8 g of (2R,5R)-2-(t-butyl)-5-((1R)-3-oxocyclopentyl)-5-phenyl-1,3-dioxolan-4-one in 30 ml of chloroform, 4.89 ml of trifluorodiethylaminosulfuric acid was added under cooling with ice, followed by 20 hours' stirring at room temperature. The reaction liquid was diluted with chloroform, washed successively with water and with saturated brine, and dried over anhydrous magnesium sulfate. Distilling the solvent off under reduced pressure, the resulting residue was purified on silica gel column chromatography (eluent: hexane/ethyl acetate=20/1) to provide 2.4 g of the title compound.

1. temperatureunder cooling with ice
2. customThe reaction liquid
3. washwashed successively with water and with saturated brine
4. dry with materialdried over anhydrous magnesium sulfate
5. distillationDistilling the solvent off under reduced pressure
6. customthe resulting residue was purified on silica gel column chromatography (eluent: hexane/ethyl acetate=20/1)