HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium sulfate decahydrate → 1-(tert-Butoxycarbonyl)-4-(2-hydroxyethyl)piperidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium sulfate decahydrate | HCID 62649 | — |
| Reactant | Ethyl 1-((1,1-dimethylethoxy)carbonyl)-4-piperidineacetate | HCID 9993342 | — |
| Reactant | Aluminium lithium hydride | HCID 21226445 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 1-(tert-Butoxycarbonyl)-4-(2-hydroxyethyl)piperidine | HCID 854140 | 93.1% |
Reaction Steps
To a solution of 263 mg of t-butyl 4-(2-ethoxy-2-oxoethyl)-tetrahydropyridine-1(2H)-carboxylate in 15 ml of tetrahydrofuran, 100 mg of lithiumaluminum hydride was added under cooling with ice, followed by 20 minutes' stirring at the same temperature. To the reaction liquid sodium sulfate decahydrate was added, stirred for 30 minutes and filtered with Celite. Distilling the solvent off under reduced pressure, 207 mg of the title compound was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06846835B2 |
| Source dataset | uspto-grants-2005_01 |
| ORD ID | ord-5b89db2a4d4d430bb6e62aeb62ab4f28 |
| Source note | uspto-grants-2005_01 |