HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → (S)-tert-Butyl 3-(2-hydroxyethyl)pyrrolidine-1-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 1,1-Dimethylethyl (3S)-3-[2-(acetyloxy)ethyl]-1-pyrrolidinecarboxylate | HCID 69766335 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | Chloroform | HCID 6212 | — |
| Product | (S)-tert-Butyl 3-(2-hydroxyethyl)pyrrolidine-1-carboxylate | HCID 29942053 | 101.9% |
Reaction Steps
To a solution of 34 mg of t-butyl(3S)-3-(2-acetyloxyethyl)pyrrolidine-1-carboxylate in 1 ml of methanol, 54 mg of potassium carbonate was added, and stirred for 2.5 hours at room temperature. The reaction liquid was diluted with chloroform, washed successively with water and saturated brine and dried over anhydrous sodium sulfate. Distilling the solvent off under reduced pressure, 29 mg of the title compound was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06846835B2 |
| Source dataset | uspto-grants-2005_01 |
| ORD ID | ord-bfa52baaa4cd43fcb64c8a566ae73f56 |
| Source note | uspto-grants-2005_01 |