Tert-butyl 4-(hydroxymethyl)piperidine-1-carboxylate → HCID 69768481, compound

HRID 1761192Notes

Reaction equation

HRID 1761192 reaction equation
[F:1][C:2]1([F:19])[C@H:6]([OH:7])[CH2:5][C@@H:4]([C@@:8]([OH:18])([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[C:9]([OH:11])=[O:10])[CH2:3]1.C(OC([N:27]1[CH2:32][CH2:31][CH:30]([CH2:33]O)[CH2:29][CH2:28]1)=O)(C)(C)C>>[F:1][C:2]1([F:19])[C@H:6]([OH:7])[CH2:5][C@@H:4]([C@@:8]([OH:18])([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[C:9]([O:11][CH2:33][CH:30]2[CH2:31][CH2:32][NH:27][CH2:28][CH2:29]2)=[O:10])[CH2:3]1

Participants

3

Reactant 2

HCID 2764081Tert-butyl 4-(hydroxymethyl)piperidine-1-carboxylateHCID 18442892HCID 18442892, compound

Product 1

HCID 69768481HCID 69768481, compound

Procedure

Using (2R)-2-((1R,4R)-3,3-difluoro-4-hydroxycyclopentyl)-2-hydroxy-2-phenylacetic acid and N-t-butoxycarbonyl-4-piperidine-methanol, the title compound was prepared by a method similar to steps 2 and 3 of Referential Example 12.

Sources & evidence

ORD record
ord-8ea430269f7b45e5afda9929b8b81e41
Source dataset
uspto-grants-2005_01
Patent number
US06846835B2

Reaction notes

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