Hydrochloric Acid → Reconcile

Participants

Reaction Steps

To a 3.0 L round bottom flask is added 25.5 g (0.0824 mol) of fluoxetine free base. To this is added 850 mL of diethyl ether and the amine is dissolved. To this solution is added 150 mL of an ethereal hydrochloric acid solution (0.069 mol HCl/100 mL). The reaction is stirred for 30 minutes and then the ether is rotoevaporated to dryness. The solid was taken up in a minimum of ethyl acetate and hexane was added until crystals started forming. The white solid is placed in the refrigerator for 14 hours at about 5° C. The solution was filtered and dried to give 25.75 g of fluoxetine hydrochloride.

Provenance & Evidence