Water → HCID 22595113, compound

Participants

Reaction Steps

Rac-trans-1,2-diaminocyclohexane (6.09 g, 53 mmol) was dissolved in 300 ml of ethanol and placed in a three-necked flask fitted with a mechanical stirrer. 3,5-Di-tert-butylsalicylaldehyde (25.0 g, 107 mmol) was then added. The mixture was subsequently refluxed for one hour, forming a red suspention. After cooling, about 100 ml of water were added dropwise while stirring. The precipitate formed was filtered off and washed with a small portion of 95% strength ethanol, giving 29.8 g of crude product. This was purified by recrystallizing it once from 350 ml of ethanol. This gave 27.18 g of pure product as a yellow powder. The yield was 94%.

Provenance & Evidence