Methyl iodide → HCID 54338931, compound

HRID 1761321Notes

Reaction equation

HRID 1761321 reaction equation
[NH2:1][C:2]1[N:3]=[C:4]([SH:12])[C:5]2[CH:11]=[CH:10][CH:9]=[N:8][C:6]=2[N:7]=1.[CH3:13]I>[OH-].[K+]>[NH2:1][C:2]1[N:3]=[C:4]([S:12][CH3:13])[C:5]2[CH:11]=[CH:10][CH:9]=[N:8][C:6]=2[N:7]=1

Participants

4

Reactant 2

HCID 6328Methyl iodideHCID 178509028HCID 178509028, compound

Product 1

HCID 54338931HCID 54338931, compound

Reagents, catalysts & solvents 1

HCID 14797Potassium HydroxideSolvent

Procedure

2-Amino-4-mercaptopyrido[2,3-d]pyrimidine (1.78 gm; 10 mmol) is dissolved in aqueous potassium hydroxide solution (1.0 gm of KOH in 25 ml of H2O), and 1 ml of methyl iodide is added at ambient temperature with stirring. After 30 minutes' reaction, the precipitated substance is subjected to suction filtration, triturated with a small amount of ethanol, and dried.

Workup

  1. customAfter 30 minutes' reaction
  2. filtrationthe precipitated substance is subjected to suction filtration
  3. customtriturated with a small amount of ethanol
  4. customdried

Sources & evidence

ORD record
ord-a853034b44bd430797591cb4e74ba143
Source dataset
uspto-grants-1989_05
Patent number
US04826528

Reaction notes

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