Methyl chloroformate → Methyl 2-bromo-4-fluorobenzoate

HRID 1761328Notes

Reaction equation

HRID 1761328 reaction equation
[Br:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1O.[OH-].[Na+].Cl[C:13]([O:15][CH3:16])=[O:14]>O>[Br:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C:13]([O:15][CH3:16])=[O:14]

Participants

5

Reactant 3

HCID 6586Methyl chloroformateHCID 14798Sodium HydroxideHCID 6054722-Bromo-4-fluorophenol

Product 1

HCID 7210837Methyl 2-bromo-4-fluorobenzoate

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

2-Bromo-4-fluorophenol (28 g) is added to a solution of sodium hydroxide (7 g) in water (100 ml), and methyl chloroformate is dropwise added thereto at a temperature below 10° C. Precipitated crystals are collected by filtration and washed with water to give methyl (2-bromo-4-fluorophenyl)formate (41 g). M.P., 80.7° C.

Workup

  1. additionis dropwise added
  2. customat a temperature below 10° C
  3. customPrecipitated crystals
  4. filtrationare collected by filtration
  5. washwashed with water

Sources & evidence

ORD record
ord-d0b0397ab1144ba5b0912561144093a4
Source dataset
uspto-grants-1989_05
Patent number
US04826533

Reaction notes

Loading…