Phenol, 2-chloro-4-fluoro-5-nitro- → 5-Amino-2-chloro-4-fluorophenol

Participants

Reaction Steps

A suspension of 2-chloro-4-fluoro-5-nitrophenol (9.17 g) and platinum dioxide (500 mg) in ethanol (120 ml) is subjected to catalytic reduction with hydrogen at room temperature and atmospheric pressure until a designed amount of hydrogen is absorbed. The catalyst is removed by filtration, and the filtrate is concentrated. The residue is extracted with ether, and the ether layer is concentrated to obtain 6.6 g of 3-amino-6-chloro-4-fluorophenol. M.P., 145°-146° C. (decomp.).

Provenance & Evidence