Water → HCID 131715065, compound

Participants

Reaction Steps

To a -78° C. solution of the resultant compound of Example 57 (1.0 g, 3.5 mmol) in dry THF (7 ml) was added 3 equivalent, of t-butoxymethyl lithium [E. J. Corey and T. M. Eckridge, Tetrahedron Letters, 3165 (1983)]. The mixture was warmed to room temperature for 4 hours and then poured into water. Acidification with 0.1 M H3PO4, extraction into ether, washing with brine, drying, and evaporating gave 1.1 (85%) of the desired compound. Mass spectrum: M+ =371.

Provenance & Evidence