N-bromobutanimide → HCID 14303120, compound

Participants

Reaction Steps

60 g (0.37 mol) of N-bromosuccinimide are added in portions to 88.8 g (0.3 mol) of 6-(4-chloro-3-methylphenoxy)-5-hydroxy-5,6,6-trimethyl-1-hexene in 600 ml of absolute chloroform, while stirring and cooling, so that the reaction temperature does not exceed 40° C. When the addition has ended, the mixture is stirred at room temperature for a further 14 hours and then washed twice with water and dried over sodium sulphate and the solvent is removed in vacuo. 94 g (82% of theory) of 2-bromomethyl-5-[2-(4-chloro-3-methylphenoxy)-prop-2-yl]-5-methyl-tetrahydrofuran are obtained and are further reacted without purification.

Provenance & Evidence