3-Methylpiperidine → HCID 53877760, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 19 g (0.07 mol) of 4-chloromethyl-2-methyl-2-[1-(3-methylthien-2-yl)-propen-2-yl]-dioxolane and 18 g (0.18 mol) of 3-methylpiperidine is heated at 120° C. for 16 hours, with stirring. For working up, the cooled reaction mixture is partitioned between water, and diethyl ether and the organic phase is separated off, dried over magnesium sulphate and evaporated in vacuo. 19 g (81% of theory) of 2-methyl-4-(3-methylpiperidin-1-yl-methyl)-2-[1-(3-methylthien-2-yl]-propen-2-yl]-dioxolane of refractive index nD20 1.5402 are obtained.

Provenance & Evidence