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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1761389Generated: October 31, 2026

Pyridine-4-carbonyl chloride → 2-[(3S,4R)-3-[(1R)-1-allyloxycarbonyloxyethyl]-4-isonicotinoylthio-2-oxo-azetidin-1-yl]-2-triphenylphosphoranylideneacetic acid allyl ester

https://huagongshe.com/reaction/1761389

Reaction equation

Participants

RoleNameHCIDCharge
ReactantPyridine-4-carbonyl chlorideHCID 417436—
Reactant2-[(3S,4R)-3-[(1R)-1-allyloxycarbonyloxyethyl]-4-mercapto-2-oxo-azetidin-1-yl]-2-triphenylphosphoranylideneacetic acid allyl esterHCID 14084562—
CatalystSilverHCID 23954—
Product2-[(3S,4R)-3-[(1R)-1-allyloxycarbonyloxyethyl]-4-isonicotinoylthio-2-oxo-azetidin-1-yl]-2-triphenylphosphoranylideneacetic acid allyl esterHCID 57297070—

Reaction Steps

3.48 g of the silver salt of 2-[(3S,4R)-3-[(1R)-1-allyloxycarbonyloxyethyl]-4-mercapto-2-oxo-azetidin-1yl]-2-triphenylphosphoranylideneacetic acid allyl ester are converted with isonicotinic acid chloride into the title compound analogously to Example 1.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS04826832
Source datasetuspto-grants-1989_05
ORD IDord-47d21f93dc6b4b488492ba749498179c
Source noteuspto-grants-1989_05