Acetic Acid → 110714-14-2

HRID 1761397Notes

Reaction equation

HRID 1761397 reaction equation
[N:1]1([C:6]2[N:11]=[N:10][C:9](Cl)=[CH:8][CH:7]=2)[CH:5]=[CH:4][N:3]=[CH:2]1.C(O)(=[O:15])C>>[N:1]1([C:6]2[CH:7]=[CH:8][C:9](=[O:15])[NH:10][N:11]=2)[CH:5]=[CH:4][N:3]=[CH:2]1

Participants

3

Reactant 2

HCID 176Acetic AcidHCID 27709033-Chloro-6-(1H-imidazol-1-yl)pyridazine

Product 1

HCID 14551076110714-14-2Yield 55%

Procedure

9.93 g (0.055 mole) of 6-(1-imidazolyl)-3-chloropyridazine [prepared according to J. Med. Chem. 24, 59 (1981)] are boiled with 7.7 g (0.0781 mole) of fused potassium acetate in 114 ml of acetic acid under reflux for 10 hours and then evaporated to dryness under reduced pressure. The residue is taken up in 200 ml of chloroform, the precipitate is filtered off, washed 4 times with water, then with ether and diisopropyl ether and dried to give 4.9 g (55% yield) of the aimed product, m. p. 239°-240° C.

Workup

  1. temperatureunder reflux for 10 hours
  2. customevaporated to dryness under reduced pressure
  3. filtrationthe precipitate is filtered off
  4. washwashed 4 times with water
  5. dry with materialwith ether and diisopropyl ether and dried

Sources & evidence

ORD record
ord-63859f0fee8a463687f86b608effa81c
Source dataset
uspto-grants-1989_05
Patent number
US04826845

Reaction notes

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