HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → 2-Chloro-6-(chloromethyl)pyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | (6-Chloropyridin-2-yl)methanol | HCID 182139 | — |
| Reactant | Sodium | HCID 5360545 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 2-Chloro-6-(chloromethyl)pyridine | HCID 15574440 | — |
Reaction Steps
6-Chloro-2-pyridylmethanol, 0.982 g (6.84 mmole) in 10 ml methylene chloride was treated with 0.814 g thionyl chloride at room temperature for one hour. The mixture was neutralized with saturated sodium bicaronate solution, extracted with methylene chloride, the extracts dried and solvent evaporated to give 815 mg of product as colorless crystals. 1H--NMR(CDCl3)ppm (delta): 4.7 (s, 2H), 7.1-8.0 (m, 3H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04826833 |
| Source dataset | uspto-grants-1989_05 |
| ORD ID | ord-9b1184cb7ddf4a91b1282065fb09db94 |
| Source note | uspto-grants-1989_05 |