HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethanol → HCID 13592494, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethanol | HCID 702 | — |
| Reactant | 5-Hydroxy-3-(propan-2-ylidene)-1,3-dihydro-2H-indol-2-one | HCID 13592492 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 13592494 | HCID 13592494 | 81% |
Reaction Steps
23 g. 5-Hydroxy-3-isopropylideneindolinone are dissolved in 100 ml. ethanol and 150 ml. tetrahydrofuran and hydrogenated in the presence of 1 g. 10% palladium-charcoal at ambient temperature and 1 bar hydrogen pressure. After filtering off the catalyst with suction, the filtrate is distilled off in a vacuum and the residue is triturated with diethyl ether and filtered off with suction. There are obtained 19 g. of the title compound; yield 81% of theory; m.p. 175° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04826847 |
| Source dataset | uspto-grants-1989_05 |
| ORD ID | ord-96d6c4a4c9a14edba5c44226dbe47f44 |
| Source note | uspto-grants-1989_05 |