7-chloro-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidine → HCID 21241318, compound

HRID 1761429Notes

Reaction equation

HRID 1761429 reaction equation
[CH3:1][O-:2].[Na+].Cl[C:5]1[N:10]2[N:11]=[CH:12][N:13]=[C:9]2[N:8]=[C:7]([CH3:14])[CH:6]=1>CO>[CH3:1][O:2][C:5]1[N:10]2[N:11]=[CH:12][N:13]=[C:9]2[N:8]=[C:7]([CH3:14])[CH:6]=1

Participants

4

Reactant 2

HCID 5201277-chloro-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidineHCID 10942334Sodium Methoxide

Product 1

HCID 21241318HCID 21241318, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent2×

Procedure

A 28% methanol solution of sodium methoxide, 2.52 g, is diluted with 50 ml of dry methanol To this, 2.00 g of 7-chloro-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidine is added at room temperature and stirred for 30 minutes. The solvent is evaporated under reduced pressure and the residue is treated with water and extracted twice with dichloromethane. The combined extract is washed with saline and dried over anhydrous potassium carbonate. Evaporation of the solvent under reduced pressure gives 1.69 g of the desired compound as colorless crystals.

Workup

  1. additionis added at room temperature
  2. customThe solvent is evaporated under reduced pressure
  3. additionthe residue is treated with water
  4. extractionextracted twice with dichloromethane
  5. extractionThe combined extract
  6. washis washed with saline
  7. dry with materialdried over anhydrous potassium carbonate
  8. customEvaporation of the solvent under reduced pressure

Sources & evidence

ORD record
ord-c3d5bfc9aadd4fd0812780a285db81e8
Source dataset
uspto-grants-1989_05
Patent number
US04826834

Reaction notes

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