Dimethylamine → HCID 54417128, compound

HRID 1761431Notes

Reaction equation

HRID 1761431 reaction equation
Cl[C:2]1[CH:3]=[CH:4][C:5]2[N:6]([N:8]=[CH:9][N:10]=2)[N:7]=1.[CH3:11][NH:12][CH3:13]>C(O)C>[CH3:11][N:12]([CH3:13])[C:2]1[CH:3]=[CH:4][C:5]2[N:6]([N:8]=[CH:9][N:10]=2)[N:7]=1

Participants

4

Reactant 2

HCID 674DimethylamineHCID 112406116-Chloro-(1,2,4)triazolo(1,5-b)pyridazine

Product 1

HCID 54417128HCID 54417128, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent2×

Procedure

6-Chloro[1,2,4]triazolo[1,5-b]pyridazine (0.9 g) is dissolved in 10 ml of ethanol, to which 10 ml of a 7.2% solution of dimethylamine in ethanol is added. The mixture is stirred at room temperature for 24 hours. After the solvent is evaporated off under reduced pressure, the residue is dissolved in methylene chloride, washed with water and a saturated aqueous solution of sodium chloride, and dried over magnesium sulfate. The solvent is evaporated off under reduced pressure to give 0.82 g of the titled compound as a white crystal.

Workup

  1. additionis added
  2. customAfter the solvent is evaporated off under reduced pressure
  3. dissolutionthe residue is dissolved in methylene chloride
  4. washwashed with water
  5. dry with materiala saturated aqueous solution of sodium chloride, and dried over magnesium sulfate
  6. customThe solvent is evaporated off under reduced pressure

Sources & evidence

ORD record
ord-fa94c88c39114f3b80465f9b4851a71a
Source dataset
uspto-grants-1989_05
Patent number
US04826834

Reaction notes

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