HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diisopropylethylamine → 8-{3-[4-(3-Methylsulfanyl-phenyl)-piperazin-1-yl]-propoxy}-8-aza-spiro[4.5]decane-7,9-dione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 1-(3-(Methylthio)phenyl)piperazine | HCID 12923180 | — |
| Reactant | 8-(3-Bromopropyloxy)-8-azaspiro[4.5]decan-7,9-dione | HCID 14280583 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | 8-{3-[4-(3-Methylsulfanyl-phenyl)-piperazin-1-yl]-propoxy}-8-aza-spiro[4.5]decane-7,9-dione | HCID 14280607 | — |
Reaction Steps
A mixture of 8-(3-bromopropyloxy)-8-azaspiro[4.5]decan-7,9-dione (4.0 g), 1-(3-methylthiophenyl)piperazine (2.75 g) and diisopropylethylamine (4.6 ml) was stirred in 100 ml of dry CH3CN at room temperature under N2.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04826846 |
| Source dataset | uspto-grants-1989_05 |
| ORD ID | ord-5edd956dc366461b8300210e50b775e0 |
| Source note | uspto-grants-1989_05 |