Methanol → HCID 14280606, compound

HRID 1761443Notes

Reaction equation

HRID 1761443 reaction equation
CO[C:3]1[CH:4]=[C:5]([N:9]2[CH2:14][CH2:13][N:12]([CH2:15][CH2:16][CH2:17][O:18][N:19]3[C:28](=[O:29])[CH2:27][C:22]4([CH2:26][CH2:25][CH2:24][CH2:23]4)[CH2:21][C:20]3=[O:30])[CH2:11][CH2:10]2)[CH:6]=[CH:7][CH:8]=1.[CH3:31][OH:32].[BH4-].[Na+]>C(Cl)Cl>[CH3:31][O:32][C:4]1[CH:3]=[CH:8][CH:7]=[CH:6][C:5]=1[N:9]1[CH2:10][CH2:11][N:12]([CH2:15][CH2:16][CH2:17][O:18][N:19]2[C:20](=[O:30])[CH2:21][C:22]3([CH2:26][CH2:25][CH2:24][CH2:23]3)[CH2:27][CH:28]2[OH:29])[CH2:13][CH2:14]1

Participants

5

Reactant 3

HCID 887MethanolHCID 4311764Sodium borohydrideHCID 14280590HCID 14280590, compound

Product 1

HCID 14280606HCID 14280606, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution prepared from 8-[3-[4-(3-methoxyphenyl)-1-piperazinyl]propyloxy]-8-azaspiro[4.5]decan-7,9-dione (5.0 g), 300 ml of CH3OH and 100 CH2Cl2 was added NaBH4 (1.8 g) with stirring. The mixture was stirred at room temperature.

Workup

  1. stirringThe mixture was stirred at room temperature

Sources & evidence

ORD record
ord-32d7e51ce99e4613bb0c03b0a7d4c379
Source dataset
uspto-grants-1989_05
Patent number
US04826846

Reaction notes

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