HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,2-Dibromoethane → 8-(2-Bromoethyloxy)-8-azaspiro[4.5]decan-7,9-dione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,2-Dibromoethane | HCID 7839 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 8-Hydroxy-8-azaspiro[4.5]decane-7,9-dione | HCID 14280582 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | 8-(2-Bromoethyloxy)-8-azaspiro[4.5]decan-7,9-dione | HCID 14500865 | — |
Reaction Steps
To a solution of 8-hydroxy-8-azaspiro[4.5]decan-7,9-dione (30 g) in 600 ml of dry CH3CN were added diisopropylethylamine (57 ml) and 1,2-dibromoethane (42.4 ml). The mixture was heated to 70° with stirring. After 7 hours, heating was discontinued and the mixture was stirred at room temperature for 48 hours.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04826846 |
| Source dataset | uspto-grants-1989_05 |
| ORD ID | ord-43f79a7d83b54c8f9abb67dd71138b48 |
| Source note | uspto-grants-1989_05 |