HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Iodide → 8-[2-(4-Benzo[d]isothiazol-3-yl-piperazin-1-yl)-ethoxy]-8-aza-spiro[4.5]decane-7,9-dione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Iodide | HCID 5238 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 3-(1-Piperazinyl)-1,2-benzisothiazole | HCID 2772144 | — |
| Reactant | 8-(2-Bromoethyloxy)-8-azaspiro[4.5]decan-7,9-dione | HCID 14500865 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | 8-[2-(4-Benzo[d]isothiazol-3-yl-piperazin-1-yl)-ethoxy]-8-aza-spiro[4.5]decane-7,9-dione | HCID 4742703 | — |
Reaction Steps
A mixture of 8-(2-bromoethyloxy)-8-azaspiro[4.5]decan-7,9-dione (3.7 g), 1-(1,2-benzisothiazol-3-yl)piperazine (2.2 g), K2CO3 (2.77 g) and NaI (200 mg) was heated was stirring in 125 mil of anhydrous CH3CN under N2.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04826846 |
| Source dataset | uspto-grants-1989_05 |
| ORD ID | ord-544ddbb65e764445bc3c0dd171db831c |
| Source note | uspto-grants-1989_05 |