Sodium Chloride → HCID 70392563, compound

Participants

Reaction Steps

490 mg of the ester (0.8 mmol) in 35 ml of chloroform is stirred together with 12 ml of hydrazine for 25 hours at room temperature. The mixture is then distributed between chloroform and saturated sodium chloride solution, the organic phase is dried with magnesium sulfate and evaporated. The crude product, amounting to 287 mg, is chromatographed on silica gel, thus isolating 193 mg of 9,10-didehydro-6-(2,2,2-trichloroethoxycarbonyl)-8-ergolinecarboxylic acid hydrazide as an oily mixture of isomers (55% of theory).

Provenance & Evidence