HCID 14536006, compound → N-[(Piperidin-4-yl)methyl]-1,3-benzoxazol-2-amine

HRID 1761489Notes

Reaction equation

HRID 1761489 reaction equation
[N:1]1[CH:6]=[CH:5][C:4]([CH2:7][NH:8][C:9]2[O:10][C:11]3[CH:17]=[CH:16][CH:15]=[CH:14][C:12]=3[N:13]=2)=[CH:3][CH:2]=1.[H][H]>CO>[NH:1]1[CH2:6][CH2:5][CH:4]([CH2:7][NH:8][C:9]2[O:10][C:11]3[CH:17]=[CH:16][CH:15]=[CH:14][C:12]=3[N:13]=2)[CH2:3][CH2:2]1

Participants

4

Reactant 2

HCID 14536006HCID 14536006, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 21241582N-[(Piperidin-4-yl)methyl]-1,3-benzoxazol-2-amine

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A mixture of 4.5 parts of N-(4-pyridinylmethyl)-2-benzoxazolamine and 120 parts of methanol was hydrogenated at normal pressure at about 50° C. with 2 parts of rhodium-on-charcoal catalyst 5%. After the calculated amount of hydrogen was taken up, the catalyst was filtered off and the filtrate was evaporated, yielding 4.6 parts of N-(4-piperidinylmethyl)-2-benzoxazolamine as an oily residue (intermediate 75).

Workup

  1. filtrationthe catalyst was filtered off
  2. customthe filtrate was evaporated

Sources & evidence

ORD record
ord-857c8950fbce42f799db45f307d6a81a
Source dataset
uspto-grants-1989_05
Patent number
US04826848

Reaction notes

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